Programme

 
You can download the final programme here
 
   Sunday, October 8
 4:00-07:00 pm  Registration
 6:00 pm
 Reception This reception is offered to you by the University of Groningen, the Municipality of Groningen and the Province of Groningen
 6:45 pm  Opening remarks - Welcome note 
7:10 pm Keynote Lecture by Andrew Dillin, Department of Molecular and Cell Biology at Berkeley 
The Communication of Mitochondrial Proteotoxic Stress (The Mitokine)
 
 
 
 8:00-8:25 pm


8:25-8:50 pm


8:50-9:10 pm


9:10-9:30 pm

Session 1. Telomeres
Chair: Michael Chang
Speakers
Joachim Lingner, École Polytechnique Fédérale de Lausanne 
Telomeric chromatin analysis provides insights into damage protection 

Jan Karlseder, Salk Institute for Biological Studies 
Regulation of DNA Repair pathway choice in S/G2 by the NHEJ inhibitor CYREN

Miguel Godinho Ferreira, Institute for Research on Cancer and Aging in Nice (IRCAN)
Non-cell autonomous effects of telomere shortening in cancer and ageing

Peter Baumann, HHMI and Stowers Institute, Kansas University Medical Center
Telomerase RNA biogenesis – it takes a lot to make enough

   Monday, October 9
 
 
 
09:00-9:25 am


9:25-9:50 am


9:50-10:10 am


10:10-10:30 am


10:30-10:50 am

Session 2. DNA repair and genome instability
Chair: Katrin Paeschke
Speakers
Jan Hoeijmakers, Erasmus MC Department of Molecular Genetics 
Keeping your genome intact protects you from aging and neurodegeneration

Penny Jeggo, School of Life Sciences at the University of Sussex 
Maintaining Genomic Integrity in the face of DNA double strand breaks

Anne Cornelis Meinema, ETH Zürich
DNA circles cause nuclear pore complex rearrangements during yeast aging
 
Jacqueline Jacobs, The Netherlands Cancer Institute
Control of DNA repair pathway choice at telomeres and DNA double strand breaks

Elsa Logarinho, IBMC-Instituto de Biologia Molecular e Celular, i3S, Porto University
Molecular basis of mitotic decline during human aging
 10:50 am  Coffee break
 


11:20-11:45 am

 
11:45-12:05 am


12:05-12:25 pm

Session 3. Mitochondria and apoptosis
Chair: Peter Lansdorp
Speakers
Liza Pon, Columbia University Medical Center 
Reciprocal interactions between mitochondrial DNA and lifespan control in budding yeast

Marte Molenaars, Academic Medical Center Amsterdam
The Interplay between Mitochondrial Function and Protein Translation in Longevity

Vincenzo Sorrentino, École Polytechnique Fédérale de Lausanne
Enhancing mitochondrial proteostasis reduces amyloid-ß peptide proteotoxicity
 12:30 am  Lunch
 
 
 
2:00-2:25 pm


2:25-2:50 pm 


2:50-3:10 pm


3:10-3:30 pm

Session 4. Nutrient Sensing
Chair: Ody Sibon
Speakers
Jens Bruening, Max Planck Institute for Metabolism Research 
Neuronal circuits in control of metabolism

Brian Kennedy, The Buck Institute for Research on Aging 
Sex Differences and Aging in the mTOR Pathway

Christine Müller, European Research Institute for the Biology of Ageing, UMCG
Reduced expression of C/EBPß-LIP extends health- and lifespan in mice

Peter Tessarz, Max Planck Institute for Biology of Ageing, Cologne
Integration of metabolic and epigenetic regulation of stem cell fates in health and ageing
 3:45 – 5:45 pm  Poster Session I; coffee and tea will be served
 6:00-7:30 pm  Dinner
 
 

7:30-7:55 pm


7:55-8:20 pm


8:20-8:45 pm


8:45-9:10 pm

Session 5. Autophagy and Immunity
Chair: Fulvio Reggiori
Speakers
David Rubinsztein, Cambridge Institute for Medical Research 
Autophagy and Neurodegeneration

Katja Simon, Oxford University 
Autophagy and immune aging

Andre Nussenzweig, Center for Cancer Research, NIH 
Genome Organization Drives Chromosome Fragility 

Manolis Pasparakis, Institute for Genetics at the University of Cologne
Necroptosis in tissue homeostasis and inflammation

   Tuesday, October 10
 
 

9:00-9:25 am


9:25-9:50 am


9:50-10:10 am



10:10-10:30 am


10:30-10:50 am 

Session 6. (Epi)genetics and ageing 
Chair: Jan Hoeijmakers
Speakers
Edwin Cuppen, Center for Molecular Medicine at the UMC Utrecht 
Tissue-specific mutation accumulation in human adult stem cells during life

Anne Brunet, Paul F. Glenn Laboratories for the Biology of Aging at Stanford University
Understanding and modeling aging 

Mario Baumgart, Leibniz Institute on Aging - FLI
Longitudinal analysis of gene expression in the short-lived killifish Nothobranchius furzeri reveals widespread pleiotropic antagonistic actions

Bart Eggen, University Medical Center Groningen
Transcriptomic analysis of purified human cortical microglia reveals age-associated changes

Markus Schosserer, University of Natural Resources and Life Sciences, Vienna
Two distinct ribosomal RNA base methylations modulate healthy lifespan
 10:55 am  Coffee break
 
 
 
11:25-11:50 am


11:50-12:10 pm



12:10-12:30 pm

Session 7A. Protein homeostasis
Chair: Ellen Nollen
Speakers
Mark S. Hipp, Max Planck Institute of Biochemistry 
Proteostasis impairment in protein misfolding and aggregation diseases

Alessandro Cellerino, Scuola Normale Superiore
Proteomic analysis of brain aging reveals reduction of protein/transcript correlation, loss of stoichiometry in multiple protein complexes and changes in protein thermal stability

Tobias Dansen, UMC Utrecht
Proteome-wide Changes in Protein Turnover Rates in C. elegans Models of Longevity and Age-Related Disease
 12:30 pm  Lunch
 
 
 
2:00-2:30 pm


2:30-3:00 pm

Session 7B. Protein homeostasis
Chair: Ellen Nollen
Speakers
Giovanna Mallucci, Department of Clinical Neurosciences, University of Cambridge 
Manipulating the Unfolded Protein Response for treatment of neurodegeneration

Collin Ewald, ETH Zurich
Preferential translation of ATF-5 mediates Caenorhabditis elegans lifespan extension from reduced protein synthesis
 

3:00-3:30 pm
 

3:30-4:00 am
 

4:00- 4:20 pm
 Session 8. Stem cells
Chair: Gerald de Haan
Speakers
Thomas Rando, Glenn Center for the Biology of Ageing at Stanford University
Epigenetics Mechanism of stem cell aging and rejuvenation

Allison Bardin, Genetics and Developmental Biology Center at Institut Curie 
Modes of genome alteration of adult stem cell during aging

Allesandro Ori, Leibniz Institute on Aging – Fritz Lipmann Institute (FLI)
Age and diet affect the intestinal crypt proteome
4:30-6:30 pm  Poster Session II; coffee and tea will be served
 7:00 pm  Reception and dinner at the Groningen Museum

   Wednesday, October 11
 
 
 
10:00-10:30 am


10:30-11:00 am 


11:00-11:30 am


11:50-12:10 am


12:10-12:30 am

Session 9. Cellular senescence
Chair: Marco Demaria
Speakers
Manuel Serrano, Institute for Research in Biomedicine, IRB Barcelona
Integrating cellular senescence and reprogramming

Sheila A. Stewart, Department of Cell Biology and Physiology at the Washington University of St. Louis 
Age-related changes in the tumor microenvironment drive tumorigenesis

Peter de Keizer, Department of Genetics, Erasmus MC Rotterdam
Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging 

Peter Bruno, Harvard Medical School
Functional genetic characterization of senescence induction

Sélène Glück, École Polytechnique Fédérale de Lausanne
Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence
 12:30 pm  Lunch & departure